With her marriage on December 10, 1843, to George Washington Glover, she became Mrs. Mary B. Glover. She was 22. George, who had a construction business in South Carolina, was eleven years older. On Christmas Day the newlyweds sailed off to Charleston.
Six months later, her husband died suddenly from yellow fever. Left nearly penniless, she returned north to the Baker home, widowed and expecting a child. There her son, George Glover, Jr., was born on September 12, 1844.
During the next years her already fragile health worsened. With Mary often incapacitated by physical suffering, her family arranged for young George to be cared for by a neighboring farm couple, Mahala and Russell Cheney.